Interleukin 1a and tissue-lytic matrix metalloproteinase-1 are elevated in ectopic endometrium of patients with endometriosis
نویسندگان
چکیده
G.Hudelist, H.Lass, J.Keckstein, I.Walter, F.Wieser, R.Wenzl, R.Mueller, K.Czerwenka, E.Kubista and C.F.Singer Department of Obstetrics and Gynecology, Division of Special Gynecology, Vienna Medical University, 1090 Vienna, Department of Obstetrics and Gynaecology, LKH Villach, 9500 Villach, Department of Obstetrics and Gynecology, Wilhelminenspital, 1060 Vienna, Department of Histology/Embryology, University of Veterinary Medicine, 1200 Vienna, Department of Obstetrics and Gynecology, Division of Endocrinology and Reproductive Medicine, Department of Clinical Pathology, Division of Gynaecopathology, Vienna Medical University, 1090 Vienna, Austria
منابع مشابه
Interleukin 1alpha and tissue-lytic matrix metalloproteinase-1 are elevated in ectopic endometrium of patients with endometriosis.
BACKGROUND Matrix metalloproteinases (MMP) play an essential role in tissue remodelling and menstruation and appear to be regulated by cytokines such as interleukin-1alpha (IL-1alpha). In order to investigate their role in the pathogenesis of endometriosis, the aim of the present study was to compare the protein localization of matrix metalloproteinase-1 (MMP-1) and of its main stimulatory cyto...
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Background & Aims: Endometriosis is defined as the presence of tissue resembling endometrium outside the uterine cavity. Extensive remodeling existence in peritoneal mesothelium layer is necessary for adhesion, invasion, and proliferation of endometrial fragments, which is required the activation of matrix metalloproteinase (MMPs), as a normal menstrual cycle. MMPs are a family of zinc dependen...
متن کاملP-182: The Role of Vascular Endothelial Growth Factor Gene Expression in Patients with the History of Endometriosis
Background: Endometriosis is the presence of endometrium- like tissue in sites outside the uterine cavity, primarily on the pelvic peritoneum and ovaries. Ectopic endometrium for replacement and growth require to blood supply. Vascular endothelial growth factor (VEGF) is one of the most important intermediate of locality angiogenesis that product by monocytes and macrophages. This study evaluat...
متن کاملEvidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix metalloproteinase-9.
BACKGROUND For the implantation of endometrium in ectopic locations, remodelling of the extracellular matrix (ECM) is necessary. Many studies have shown an increased expression of various proteases in the ectopic endometrium of women with endometriosis. Few, however, have addressed possible changes in protease expression in the eutopic endometrium. METHODS AND RESULTS Herein, we reveal an inc...
متن کاملP-136: Association of Matrix MetalloProteinase- 2,-9 Overexpression and Imbalance PR-A/PR-B Ratio in Endometriosis
Background: Matrix MetalloProteinases (MMPs) degrade extracellular matrix components to provide normal remodeling and contribute to pathological tissue destruction and cell migration in endometriosis. It is accepted that MMPs are resistant to suppression by progesterone in endometriotic tissues. The physiological effects of progesterone are mediated by its two progesterone receptor (PR) isoform...
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